Two New Phorbol-Type Diterpene Esters from Synadenium grantii Hook F. Leaves
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چکیده
Two new phorbol-type diterpene esters have been isolated from the chloroform extract of the leaves of Synadenium grantii Hook F. and identified as 3,4,12,13-tetraacetylphorbol-20-phenylacetate and 4deoxyphorbol-12,13-ditiglate for which the trivial names Synagrantol A & B respectively, were adopted. Furthermore, two known triterpenes were isolated. The structures of all isolated compounds were established by 1D and 2D NMR spectroscopy including H and C NMR, HSQC and HMBC techniques. The cytotoxicity as well as the antiparasitic activity of the chloroform extract was performed and proved to be active.
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